Development of Nanoemulsion as Carrier for Transdermal Delivery of Valsartan
نویسندگان
چکیده
The aim of the present study was to develop potential nanoemulsion for transdermal delivery of valsartan. The o/w nanoemulsion was prepared by screening the excipients from the nanoemulsion region of pseudoternary phase diagram. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The composition of optimized formulation was Triacetin (13.6%), Chemophore EL (23.9%), PEG 400 (7.9%), and water (54.6%) as oil, surfactant, co-surfactant and aqueous phase, respectively, showing globule size (4.49 nm), polydispersity (0.651), and viscosity (82.55 ± 3.12 cP). The in vitro permeation of valsartan through rat skin was found to be significantly (p < 0.01) increased as compared to conventional gel formulation. The present study revealed that the nanoemulsion as suitable carrier for transdermal delivery of valsartan.
منابع مشابه
Pharmaceutical Nanoemulsions and Their Potential Topical and Transdermal Applications
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